sympy: substitution by the value of a symbol

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Sir,

Is it possible to use the value of a variable to make a subsitution ?

Example:

x = symbols("x")

c = IndexedBase("c")

eq1 = c[0] + c[1]*x+c[2]*x**2

x1 = 2

eq1.subs(x,x1)

Nothing change. How can we use the value of x1, here 2 ?

Sincerely.

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