Outlook Translator returns error when with on-prem exchange server

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Environment consists of on-prem Exchange Server 2016CU22 in a DAG configuration sitting behind a Barracuda ADC load balancer configured to load balance POP3, SMTP, and Outlook 2016 client connections(instantSSL service). Have added the Outlook Translator add-in both on the exchange server and also directly into Outlook. When trying to translate an email, receive the following error:

An error occurred. Please try again. Session Id: 28db8d22-13bf-403b-9a3b-4ca69ca705d6

We also have a test exchange server, same version and CU. When configuring an outlook profile to connect to the test server, the translator add-in works perfectly every time. Have been working with Microsoft for over a month and they cannot figure out where the issue lies. They suggested posting to this forum to see if anyone else has run into this issue. They said that since translation communication happens between the client and the microsoft translation site, the server and load balancer should not come into play.

When using OWA and turning browser debugging on, we can see connections from the client out to https://eu.ogma.osi.office.net/outlooktranslatorapp/api/translate that just sit in a pending state. But when connecting to the test exchange server, these connections complete immediately.

We are at a loss to where the problem lies. Any help/suggestions would be greatly appreciated.

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