Other options than using engine "openpyxl" in python

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Currently I'm using the engine "openpyxl" in Python to replacing data in excel. It cost me almost 54 min to go through 250k lines. Are there other engine options?

I tried to use xlsxwriter but I my code I need to use mode'a' as well, what is not allowed in xlswriter.

with pd.ExcelWriter(new_file,  mode='a',engine='openpyxl', if_sheet_exists='replace') as writer:
    df.to_excel(writer, sheet_name='Data', startrow=0, startcol=0)
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