Mac: Opening large files creates `invalid argument` error

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I am currently trying to open a large file on my 64 bit Mac (using 64 bit Miniconda, as this is the only version for mac). I use a framework 'sumatra' which is a library to track scientific computing work and possibly reproduce it. I get the following error. I was able to debug a little, and found out that it is mainly due to X_train.npy being too big (3.6GB when not unpacked).

Traceback (most recent call last):
  File "/Users/davidal/miniconda3/envs/ml_project/bin/smt", line 31, in <module>
    main(sys.argv[2:])
  File "/Users/davidal/miniconda3/envs/ml_project/lib/python3.5/site-packages/sumatra/commands.py", line 372, in run
    project.allow_command_line_parameters)
  File "/Users/davidal/miniconda3/envs/ml_project/lib/python3.5/site-packages/sumatra/commands.py", line 76, in parse_arguments
    parameters = build_parameters(arg)
  File "/Users/davidal/miniconda3/envs/ml_project/lib/python3.5/site-packages/sumatra/parameters.py", line 586, in build_parameters
    parameters = parameter_set_class(filename)
  File "/Users/davidal/miniconda3/envs/ml_project/lib/python3.5/site-packages/parameters/__init__.py", line 387, in __init__
    pstr = f.read()
OSError: [Errno 22] Invalid argument

Any experience resolving such issues? Where should I look further? Any ideas?

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