host different frameworks IIS

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I have windows server 2003 with IIS6 installed. I installed both framework 2 and 4 on the IIS. The applications that using Framework2 are running perfectly , when I try to host framework4 application I get this error:

The resource cannot be found

Please advise,

Thank you

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Ahmed Elshorbagy On BEST ANSWER

I solved the problem by creating a different application pool on IIS