What is a good Laplacian operator for reaction diffusion algorithms, with spherical symmetry?

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I am doing reaction diffusion computing and I get artifacts related to the Cartesian coordinate system in combination with the design of the Laplacian operator. The initial circularly symmetric seed develops into Laplacian operator defects

where the upper left structure uses a traditional vertical horizontal Laplacian and the upper right structure a Laplacian with diagonals added. Lower left is a Laplacian calculated from the 12 closest points and lower right 20 points. Even the 20 point version decays after a while. The code for this is at https://www.shadertoy.com/view/3sGXWG

Is there a better or a "best" Laplacian operator to use in situations like this? Someone suggested hexagonal and Fourier coordinates.

I even accept answers involving other coordinate systems, provided they are transformable back to the Cartesian coordinates for viewing on computer screens.

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