I have stumbled into an issue that is really annoying.
When I debug my software, everything runs OK, but if I hit a breakpoint and edit the code, when I try to continue running I get an error:
Metadata file 'XYZ' could not be found
After looking around for a while, I found some a similar issues, but they were all regarding a build failure, which is not my case (this happens only after edit-continue).
What I have tried so far:
- My code is compiling and running.
- I cleaned the solution and restarted VS.
- I made sure that the missing file's project is being build for the configuration I am running (in configuration manager).
- I manually built the missing file's project.
Some extra info:
- It does not matter what I change, still get the same error (the change is not related to the missing file).
- This happens also when I pause and continue (not only breakpoints)
- I am running the project using a custom configuration (configuration manager...). When I run it using the default
Debugconfiguration the error does not occur.
Any ideas?

Eventually what solved the issue was:
I guess for some reason, just cleaning the solution had a different effect than specifically cleaning every project individually.
Edit:
As per @maplemale comment, It seems that sometimes removing and re-adding each reference is also required.
Update 2019:
This question got a lot of traffic in the past, but it seems that since VS 2017 was released, it got much less attention.
So another suggestion would be - Update to a newer version of VS (>= 2017) and among other new features this issue will also be solved