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Programmatically set Outlook 2013 Signature Defaults?

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Is it possible to programmatically set the Outlook 2013 Default Signature settings? We can generate the user's signature OK but would like to also set the signature to appear by default in user's emails:

Outlook 2013 Email Signature Defaults

The setting itself seems to be tucked-away in the Registry under an Outlook profile:


Reg Values:

  • New Signature
  • Reply-Forward Signature

... (which have binary data, presumably encoding the HTML file name/reference).

Not sure if I can use the Outlook Object Model to access and set settings? And whether this would be possible with a ClickOnce application?

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