Network meta-regression with R

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I need to perform a network meta-regression on the attached dataset (metareg). Four interventions are assessed: cot, hfno, cpap, niv.

VARIABLES

id: study id author: study author prophylactic: first mediator variable (factor) surgery: second mediator variable (factor) risk: third mediator variable (factor) setting: fourth mediator variable (factor) intervention_1: first intervention tested (either cot, hfno, cpap, niv) intervention_2: second intervention tested (either cot, hfno, cpap, niv) n_tot: total number of patients in the study n_1 : number of patients receiving the first intervention n_2: number of patients receiving the second intervention reeeti_1: number of patients developing the outcome with the first intervention reeeti_2: number of patients developing the outcome with the second intervention md_logor: mean difference or log odds ratio se: standard error

DATASET (just reported the first 6 studies, but the dataset includes 33 studies) enter image description here I would need to perform 4 single meta-regressions based on the above-mentioned mediator variables (prophylactic, surgery, risk, setting). Please please please, help me! Thank you very much! I could not perform the network meta-regression under a frequentist approach

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