In BizTalk, unable to send file from local to SharePoint online

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As the title says, I am trying to send files from local directory to a SharePoint online site with BizTalk. I am unable to do so for days and days... read tons of topic about it but nothing is working, I am a bit discouraged to be honest at the moment...

Here is how my send port is currently configured :

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The account used has full access granted on the SharePoint site. I can log in with it using a browser without any issue, I can upload files as well.

Here is the error I encounter when trying to send a file :

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I am using BizTalk 2016 with SharePoint Online.

If someone has an idea on how I could resolve this, I would be very very grateful.

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Dijkgraaf On

BizTalk, or rather the .Net layer defaults to using older TLS protocols, namely TLS 1.0, and doesn't then negotiate up.

To address this you need make sure you have CU5 for BizTalk Server 2016 or later (currently CU8) and then follow the steps in "Option 1: Switch to the TLS 1.2 protocol" section of the following article in the Microsoft Knowledge Base:" as per the article Support for TLS 1.2 protocol in BizTalk Server

3155464 MS16-065: Description of the TLS/SSL protocol information disclosure vulnerability (CVE-2016-0149): May 10, 2016

or

Use the scripts from the following Setup Microsoft Windows or IIS for SSL Perfect Forward Secrecy and TLS 1.2

Note: You will have to test to make sure no other system BizTalk connects to still uses TLS 1.0 or 1.1, and if so not to disable those, but to try to default to 1.2.