Game Theory: how to apply it in transcriptomics?

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Hi

I have seen this paper (and also Game Theory applied to gene expression analysis, Game Theory and Microarray Data Analysis) authors have used game theory for their microarray DEG analysis (microarray game).

Is there any simple guide from you (or other online resources) that can describe how to use related formula for checking game theory concept in the DEG analysis of RNA-seq experiences ? (Basically is it even practical?)

Maybe there is some software for doing such investigation, painlessly.

NOTE1: For example please have a look at "Game Theory Method" in the first paper above :

Let N 5 {1,. . .,n} be a set of genes. A microarray game is a coalitional game (N, w) where the function w assigns to each coalition S ( N a frequency of associations, between a condition and a expression property, of genes realized in the coalition S."

Imagin we have 150 gene up-regulated in females and 80 up-regulated in males (using de novo assembly and DESeq2 package), now how I can use game theory for mining something new or some extra connections between this collection of genes?

NOTE2: I have asked this question in BIOSTARS but no answer after 8 weeks.

Thanks

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