Installing Canopy 2.1.9 for Windows 64-bit on Windows 10, and the installer fails immediately after clicking the Install button, with the message "Enthought Canopy (64-bit) Setup Wizard ended prematurely because of an error." Same result using 2.1.8. Same result using the run-as-administrator command line msiexec instructions, same result running the installer as administrator, same result installing for current user or all users.
Enthought support here. Sounds like there's something unusual about your current system status. Most likely would be interference from a 3rd-party anti-virus program, or similar. If temporarily disabling that doesn't help, then please run
msiexec /Lv*x canopy-msi.log ... etc..., then zip and send the resulting log, with a link to this SO question, to [email protected]. We'll look at it as time permits, though we do not have the bandwidth to help you debug your system setup.